Our team's response, in paraphrase:
Students have write access within their profile so it's not a permissions issue. Since the Mac has no real equivalent of a roaming profile, we approximate one by manually copying things locally from the user's profile filestore whenever they log on, and then copying those same things back up again on logoff. Not everything is copied because particular things don't tolerate being stored on NTFS and come back broken, so we implement a list of exclusions. In this case, we have added ../Application Support/Wwise2016 folder to the exclusion list. The Wwise2016 subtree is full of symbolic links, which are particularly problematic for our copy-up/copy-down process. Previously, logging off meant copying up most of a user's Wwise2016 subtree, but excluding the symbolic links. Upon logging on again, everything copied up would be copied back down, minus the symbolic links. Consequently, Wwise was unable to find the things that should have been down those links, and therefore would break.
It would be great to see a version of the Wwise authoring app that could run natively in OS X sometime in the future, but hopefully this workaround will be helpful now for those in the same boat.